Biochemical Principles of the Use of Xylitol in Medicine and by K. Mäkinen
By K. Mäkinen
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Extra info for Biochemical Principles of the Use of Xylitol in Medicine and Nutrition with Special Consideration of Dental Aspects
The previously presented considerations of molecular genetics support this idea. 41 Inhibition The ability of xylito1 to inhibit certain enzyme reactions may be manifested as an inhibition of the trans10cation of sugars across bacterial cell membranes. Various mechanisms invo1ved in the transport exist, for example: - Phosphotransferase system. - Permease system. - Specific sugar-binding proteins. - Free diffusion. The transport of xylito1 across the bacteria1 cell membrane does not most like1y take p1ace through free diffusion.
Polyols clearly exhibit selective effects in the oral cavity. 6 Facilitation of mineralization by xylitol The consumption of xylitol in the Turku sugar studies decreased the incidence of dental caries in man by more or less than 100% when compared to the consumption of sucrose. The exact degree of reduction depended on the type of test person and the way the results were expressed. The results were obtained by clinical and radiographic examinations. The reduction of caries incidence was accompanied by remineralization of caries lesions [99-10 1].
Rowever, the physiological, organoleptic and other properties ofxylitol seem to place it first among present carbohydrate sweeteners in human diet. The history of polyol research in dentistry has been short; scant in the beginning and impetuous in the recent years. There have also been certain misconceptions related to the molecular properties of sorbitol and xylitol. Certain scientists have maintained that all polyols should have a similar effect on dental caries. 3. Polyols clearly exhibit selective effects in the oral cavity.